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From self to non-self
ROX MIDDLETON, LIAM SHAW and JOEL HELLEWELL explain how stem-cell transplants provide new immune systems for those who need them

IN THE coming weeks and months, the National Health Service will be tested to its limits, striving to save as many patients as possible who are seriously ill due to the coronavirus. 

The surges in intensive-care patient numbers will cause major disruption to the routine work of the NHS, which includes crucial life-saving procedures.
 
One such procedure that has been particularly affected by international travel disruption has been stem-cell donation, for the treatment of conditions such as blood cancer. 

Once the donation has been made, the stem cells need to be transplanted into the recipient within 72 hours.
 
Our immune system uses special structures on the surfaces of cells called antigens to recognise cells that belong to our own body (“self”). 

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